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Version: 17.06d (Release date: 2017-06-26)
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BET Inhibitor CPI-0610 (Code C111901)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BET Inhibitor CPI-0610

Definition: A small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor CPI-0610 binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of two bromodomains at the N-terminus, the BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that play an important role during development and cellular growth.

Display Name: BET Inhibitor CPI-0610

Label: BET Inhibitor CPI-0610

NCI Thesaurus Code: C111901 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454233  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BET Inhibitor CPI-0610
CPI-0610

External Source Codes: 
PDQ Closed Trial Search ID 753680
PDQ Open Trial Search ID 753680 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454233

Other Properties:
     Name Value (qualifiers indented underneath)
code C111901
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111901

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