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Version: 17.06d (Release date: 2017-06-26)
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Ondansetron (Code C1119)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ondansetron

Definition: A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Ondansetron is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Ondansetron

Label: Ondansetron

NCI Thesaurus Code: C1119 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0061851  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ondansetron
ondansetron
ONDANSETRON
Zofran ODT

External Source Codes: 
CAS Registry Number 116002-70-1 (see NLM ChemIDplus info)
CAS Registry Number 99614-02-5 (see NLM ChemIDplus info)
FDA UNII Code 4AF302ESOS
PDQ Closed Trial Search ID 40693
PDQ Open Trial Search ID 40693 (check for NCI PDQ open clinical trial info)
UMLS CUI C0061851

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
Chemical_Formula C18H19N3O
code C1119
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ondansetron
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1119

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