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Version: 17.06d (Release date: 2017-06-26)
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Ondansetron (Code C1119)

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Terms & Properties

Preferred Name: Ondansetron

Definition: A carbazole derivative with antiemetic activity. As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)

NCI-GLOSS Definition: The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. Ondansetron is a type of serotonin receptor antagonist and a type of antiemetic.

Display Name: Ondansetron

Label: Ondansetron

NCI Thesaurus Code: C1119 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0061851  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Zofran ODT

External Source Codes: 
CAS Registry Number 116002-70-1 (see NLM ChemIDplus info)
CAS Registry Number 99614-02-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 40693
PDQ Open Trial Search ID 40693 (check for NCI PDQ open clinical trial info)
UMLS CUI C0061851

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
Chemical_Formula C18H19N3O
code C1119
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ondansetron
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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