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Version: 17.12d (Release date: 2017-12-26)
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Donor Regulatory T-lymphocytes (Code C111894)

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Terms & Properties

Preferred Name: Donor Regulatory T-lymphocytes

Definition: Donor-derived regulatory T-cells (Tregs), with potential immunomodulating activity. Tregs are a subset of CD4+ T cells that express high levels of CD25 (interleukin 2 receptor) and the transcription factor Foxp3. The donor CD4+CD25+ Tregs modulate immune responses and may induce tolerance to allogeneic organ transplants, such as hematopoietic stem cell transplants (HSCTs), thereby preventing graft-versus-host disease (GVHD).

Display Name: Donor Regulatory T-lymphocytes

Label: Donor Regulatory T-lymphocytes

NCI Thesaurus Code: C111894 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454227  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Donor CD4+CD25+FoxP3+ T Cells
Donor Regulatory T-lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 753335
PDQ Open Trial Search ID 753335 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C111894
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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