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Version: 17.06d (Release date: 2017-06-26)
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PEG-Proline-Interferon Alfa-2b (Code C111892)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PEG-Proline-Interferon Alfa-2b

Definition: A long-acting formulation of recombinant interferon alpha subtype 2b (IFN-a2b) protein, in which IFN-a2b is coupled, via proline, to polyethylene glycol (PEG), with antiviral, immunomodulating and antineoplastic activities. Upon subcutaneous administration, IFN-a2b binds to specific interferon cell-surface receptors. This activates interferon-mediated signal transduction pathways and induces the transcription and translation of genes with interferon-specific response elements (ISREs); the protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety inhibits proteolytic breakdown and clearance of IFN-a2b, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing. The proline linker facilitates the synthesis of a predominant (90%) positional isomer which allows for further increases in stability and a longer half-life than previous PEG conjugates.

Label: PEG-Proline-Interferon Alfa-2b

NCI Thesaurus Code: C111892 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827091  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AOP2014
P1101
PEG-P-IFN-Alfa-2b
PEG-P-IFN-Alpha-2b
PEG-Proline-Interferon Alfa-2b

External Source Codes: 
PDQ Closed Trial Search ID 753252
PDQ Open Trial Search ID 753252 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827091

Other Properties:
     Name Value (qualifiers indented underneath)
code C111892
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111892

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