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Version: 17.06d (Release date: 2017-06-26)
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Carbon C 14 Telotristat Etiprate (Code C111891)

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Terms & Properties

Preferred Name: Carbon C 14 Telotristat Etiprate

Definition: An orally bioavailable, tryptophan hydroxylase (TPH) inhibitor prodrug labeled with carbon C 14, which could be used to evaluate the pharmacokinetic profile of telotristat etiprate. Upon administration, telotristat etiprate is converted to its active moiety, telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal adverse side effects, such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells. Telotristat radiolabeled with carbon C 14 facilitates the evaluation of the pharmacokinetic characteristics of this agent, including its absorption, distribution, metabolism, and excretion (ADME).

Label: Carbon C 14 Telotristat Etiprate

NCI Thesaurus Code: C111891 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454225  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
14C-telotristat Etiprate
[14C]-telotristat Etiprate
Carbon C 14 Telotristat Etiprate

External Source Codes: 
PDQ Closed Trial Search ID 753248
PDQ Open Trial Search ID 753248 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C111891
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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