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Version: 17.06d (Release date: 2017-06-26)
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Selatinib Ditosilate (Code C111764)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Selatinib Ditosilate

Definition: An orally bioavailable ditosilate salt form of selatinib, an analog of the quinazoline lapatinib and dual inhibitor of epidermal growth factor receptor (EGFR) and Human Epidermal Growth Factor Receptor 2 (ErbB-2 or HER-2), with potential antineoplastic activity. Upon administration, selatinib reversibly blocks phosphorylation of both EGFR and ErbB2, thereby suppressing tumor growth in EGFR/ErbB-2-overexpressing tumor cells. The tyrosine kinases EGFR and ErbB2 have been implicated in the growth of various tumor types.

Label: Selatinib Ditosilate

NCI Thesaurus Code: C111764 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454151  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Selatinib Ditosilate

External Source Codes: 
PDQ Closed Trial Search ID 753197
PDQ Open Trial Search ID 753197 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454151

Other Properties:
     Name Value (qualifiers indented underneath)
code C111764
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111764

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