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Version: 17.06d (Release date: 2017-06-26)
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Triptolide Analog (Code C111762)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Triptolide Analog

Definition: A water soluble analog of the diterpenoid triepoxide triptolide isolated from the Chinese herb Tripterygium wilfordii Hook.f., with potential antineoplastic activity. Upon intravenous administration, the triptolide analog inhibits heat shock protein 70 (HSP70) and prevents HSP70-mediated inhibition of apoptosis. This leads to both the induction of apoptosis and a reduction of cancer cell growth. HSP70, a molecular chaperone upregulated in various cancer cells, plays a key role in the inhibition of caspase-dependent and -independent apoptosis.

Display Name: Triptolide Analog

Label: Triptolide Analog

NCI Thesaurus Code: C111762 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3657815  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Minnelide
Triptolide Analog

External Source Codes: 
PDQ Closed Trial Search ID 753195
PDQ Open Trial Search ID 753195 (check for NCI PDQ open clinical trial info)
UMLS CUI C3657815

Other Properties:
     Name Value (qualifiers indented underneath)
code C111762
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111762

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