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Version: 17.06d (Release date: 2017-06-26)
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JAK Inhibitor INCB047986 (Code C111761)

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Terms & Properties

Preferred Name: JAK Inhibitor INCB047986

Definition: An orally bioavailable inhibitor of Janus-associated kinases (JAK), with potential antineoplastic activity. Upon oral administration, INCB047986 specifically binds to and inhibits the phosphorylation of JAK, which affects JAK-dependent signaling and may lead to an inhibition of cellular proliferation in JAK-overexpressing tumor cells. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies.

Label: JAK Inhibitor INCB047986

NCI Thesaurus Code: C111761 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454148  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
INCB-047986
INCB047986
INCB 047986
JAK Inhibitor INCB047986

External Source Codes: 
PDQ Closed Trial Search ID 753081
PDQ Open Trial Search ID 753081 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454148

Other Properties:
     Name Value (qualifiers indented underneath)
code C111761
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111761

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