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Version: 17.06d (Release date: 2017-06-26)
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Activated Marrow Infiltrating Lymphocytes (Code C111759)

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Terms & Properties

Preferred Name: Activated Marrow Infiltrating Lymphocytes

Definition: A preparation of cells, which consists of autologous marrow infiltrating lymphocytes (MILs), that are manipulated in vitro, with potential antitumor and immune stimulating activities. MILs are harvested from autologous bone marrow from multiple myeloma patients and, in vitro, are exposed to and activated by anti-CD3/anti-CD28 monoclonal antibodies covalently attached to super-paramagnetic microbeads. After removal of the beads and expansion of the cells in culture, the activated MILs (aMILs) are re-introduced into the patient. The aMILs possess enhanced myeloma specificity, and are able to infiltrate the tumor microenvironment and initiate tumor cell lysis. CD3 and CD28, co-stimulatory molecules expressed on the surface of T-lymphocytes, play a key role in the activation of T-cells.

Display Name: Activated Marrow Infiltrating Lymphocytes

Label: Activated Marrow Infiltrating Lymphocytes

NCI Thesaurus Code: C111759 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454146  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Activated Marrow Infiltrating Lymphocytes
aMIL

External Source Codes: 
PDQ Closed Trial Search ID 753013
PDQ Open Trial Search ID 753013 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454146

Other Properties:
     Name Value (qualifiers indented underneath)
code C111759
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111759

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