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Version: 17.06d (Release date: 2017-06-26)
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Mercaptopurine Oral Suspension (Code C111757)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Mercaptopurine Oral Suspension

Definition: An oral suspension containing the thiopurine-derivative antimetabolite 6-mercaptopurine, with potential antineoplastic activity. Upon oral administration, mercaptopurine is metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions and de novo purine ribonucleotide synthesis, which both blocks the formation of purine nucleotides and inhibits DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. By blocking DNA synthesis and replication, cancer cells are unable to proliferate. Compared to the tablet formulation, the liquid is easier to swallow and offers more flexibility and accuracy in dosing, which is beneficial for use in pediatric patients.

Label: Mercaptopurine Oral Suspension

NCI Thesaurus Code: C111757 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3820263  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-MP Oral Suspension
Mercaptopurine Oral Suspension
Purixan
Xaluprine

External Source Codes: 
PDQ Closed Trial Search ID 752956
PDQ Open Trial Search ID 752956 (check for NCI PDQ open clinical trial info)
UMLS CUI C3820263

Other Properties:
     Name Value (qualifiers indented underneath)
code C111757
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111757

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