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Version: 17.06d (Release date: 2017-06-26)
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HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001 (Code C111689)

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Terms & Properties

Preferred Name: HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001

Definition: A peptide-based cancer vaccine consisting of two human leukocyte antigen (HLA)-A*0201 restricted 9-mer epitopes derived from the human telomerase reverse transcriptase (hTERT), TERT 572Y (YLFFYRKSV; TYR-Vx001) and TERT 572 (RLFFYRKSV; ARG-Vx001), with potential immunostimulating and antineoplastic activities. Subcutaneous injection of TERT(572Y) peptide followed by subcutaneous administration of the TERT(572) peptide may elicit a specific and possibly optimal cytotoxic T cell (CTL) response against hTERT-expressing tumor cells. hTERT, the catalytic subunit of human telomerase, is an human leukocyte antigen-A*0201-restricted cryptic epitope of telomerase. TERT is expressed in the majority of human cancer cells, is not expressed or is expressed at very low levels in normal cells and plays a key role in tumorigenesis. TERT572Y is the optimized variant of the native cryptic peptide TERT572 in which tyrosine has been substituted for an arginine at position 1; TERT572Y shows increased HLA-A*0201 binding affinity compared to TERT572.

Label: HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001

NCI Thesaurus Code: C111689 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1958472  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HLA-A*0201 Restricted Telomerase-specific Vaccine Vx-001
HLA-A*0201 Restricted TERT(572Y)/TERT(572) Peptides Vaccine Vx-001
Vx-001
Vx001

External Source Codes: 
PDQ Closed Trial Search ID 752897
PDQ Open Trial Search ID 752897 (check for NCI PDQ open clinical trial info)
UMLS CUI C1958472

Other Properties:
     Name Value (qualifiers indented underneath)
code C111689
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111689

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