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Version: 17.06d (Release date: 2017-06-26)
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ALK-FAK Inhibitor CEP-37440 (Code C111685)

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Terms & Properties

Preferred Name: ALK-FAK Inhibitor CEP-37440

Definition: An orally available dual kinase inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and focal adhesion kinase (FAK), with potential antineoplastic activity. Upon administration, ALK-FAK inhibitor CEP-37440 selectively binds to and inhibits ALK kinase and FAK kinase. The inhibition leads to disruption of ALK- and FAK-mediated signal transduction pathways and eventually inhibits tumor cell growth in ALK- and FAK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development; its dysregulation and gene rearrangements are associated with a variety of tumors. The cytoplasmic tyrosine kinase FAK, a signal transducer for integrins, is upregulated and constitutively activated in various tumor types; it plays a key role in tumor cell migration, proliferation, survival, and tumor angiogenesis.

Display Name: ALK-FAK Inhibitor CEP-37440

Label: ALK-FAK Inhibitor CEP-37440

NCI Thesaurus Code: C111685 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454076  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALK-FAK Inhibitor CEP-37440
CEP-37440

External Source Codes: 
PDQ Closed Trial Search ID 752740
PDQ Open Trial Search ID 752740 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454076

Other Properties:
     Name Value (qualifiers indented underneath)
code C111685
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111685

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