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Version: 17.06d (Release date: 2017-06-26)
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Imisopasem Manganese (Code C111684)

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Terms & Properties

Preferred Name: Imisopasem Manganese

Definition: A manganese-based non-peptidyl mimetic of the human mitochondrial manganese superoxide dismutase (MnSOD), with potential antioxidant and chemo/radioprotective activities. Upon administration, imisopasem manganese mimics the activity of MnSOD and scavenges reactive oxygen species (ROS), such as superoxide anion, which prevents oxygen free radical damage to macromolecules such as DNA. This reduces ROS-mediated lipid peroxidation, prevents apoptosis and protects against oxygen free radical-induced toxicity in normal tissues.

Display Name: Imisopasem Manganese

Label: Imisopasem Manganese

NCI Thesaurus Code: C111684 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3502536  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GC4419
Imisopasem Manganese
M40403
Manganese, dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7Hdibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-kN5,kN13,kN18,kN21,kN22]-, (PB-7-11-2344'3')-

External Source Codes: 
CAS Registry Number 218791-21-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 752697
PDQ Open Trial Search ID 752697 (check for NCI PDQ open clinical trial info)
UMLS CUI C3502536

Other Properties:
     Name Value (qualifiers indented underneath)
code C111684
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111684

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