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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 5-Fluoro-2-deoxycytidine (Code C111682)

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Terms & Properties

Preferred Name: Fluorine F 18 5-Fluoro-2-deoxycytidine

Definition: A radioconjugate composed of a fluorinated pyrimidine analog, linked to the radioisotope fluorine F 18 with potential imaging activity using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 5-fluoro-2-deoxycytidine ([F-18]-FdCyd), the FdCyd moiety is phosphorylated by deoxycytidine kinase to 5-fluoro-2'-deoxycytidylate (FdCMP) and deaminated by deoxycytidylate (dCMP) deaminase, an enzyme overexpressed by tumor cells, to 5-fluoro-2-deoxyuridine monophosphate (FdUMP). Eventually, FdUMP is metabolized to the triphosphate forms 5-fluoro-2'-deoxycytidine-triphosphate (FdCTP) and fluorodeoxyuridine triphosphate (FdUTP). FdCTP and FdUTP inhibit DNA methyltransferase (DNMT) and DNA methylation, and induce DNA strand breaks, respectively. FdCyd is coadministered with tetrahydrouridine (THU), an inhibitor of cytidine/deoxycytidine deaminase, which prevents FdCyd breakdown and increases its efficacy. The fluorine F 18 moiety can be imaged upon PET/CT, thereby allowing for the evaluation of the biodistribution of FdCyd and its uptake by tumor cells.

Display Name: Fluorine F 18 5-Fluoro-2-deoxycytidine

Label: Fluorine F 18 5-Fluoro-2-deoxycytidine

NCI Thesaurus Code: C111682 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454074  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[F-18]-5-fluoro-2'-deoxycytidine
[F-18]-FdCyd
Fluorine F 18 5-Fluoro-2-deoxycytidine

External Source Codes: 
PDQ Closed Trial Search ID 752695
PDQ Open Trial Search ID 752695 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454074

Other Properties:
     Name Value (qualifiers indented underneath)
code C111682
Contributing_Source CTRP
Semantic_Type Indicator, Reagent, or Diagnostic Aid
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111682

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