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Version: 17.06d (Release date: 2017-06-26)
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AKT 1/2 Inhibitor BAY1125976 (Code C111575)

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Terms & Properties

Preferred Name: AKT 1/2 Inhibitor BAY1125976

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) isoforms 1 and 2 (AKT1/2) with potential antineoplastic activity. AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway. This may lead to both the reduction of cell proliferation and the induction of cell apoptosis in AKT-overexpressing tumor cells. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.

Display Name: AKT 1/2 Inhibitor BAY1125976

Label: AKT 1/2 Inhibitor BAY1125976

NCI Thesaurus Code: C111575 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL453983  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AKT 1/2 Inhibitor BAY1125976
BAY1125976

External Source Codes: 
PDQ Closed Trial Search ID 752318
PDQ Open Trial Search ID 752318 (check for NCI PDQ open clinical trial info)
NCI META CUI CL453983

Other Properties:
     Name Value (qualifiers indented underneath)
code C111575
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111575

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