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Version: 17.06d (Release date: 2017-06-26)
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IDH2 Inhibitor AG-221 (Code C111573)

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Terms & Properties

Preferred Name: IDH2 Inhibitor AG-221

Definition: An orally available inhibitor of isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity. Upon administration, AG-221 specifically inhibits IDH2 in the mitochondria, which inhibits the formation of 2-hydroxyglutarate (2HG). This may lead to both an induction of cellular differentiation and an inhibition of cellular proliferation in IDH2-expressing tumor cells. IDH2, an enzyme in the citric acid cycle, is mutated in a variety of cancers; It initiates and drives cancer growth by blocking differentiation and the production of the oncometabolite 2HG.

Display Name: IDH2 Inhibitor AG-221

Label: IDH2 Inhibitor AG-221

NCI Thesaurus Code: C111573 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827168  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AG-221
CC-90007
IDH2 Inhibitor AG-221

External Source Codes: 
CAS Registry Number 1802003-09-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 752247
PDQ Open Trial Search ID 752247 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827168

Other Properties:
     Name Value (qualifiers indented underneath)
code C111573
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111573

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