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Version: 17.12d (Release date: 2017-12-26)
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Carbon C 14 Oxaliplatin (Code C111572)

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Terms & Properties

Preferred Name: Carbon C 14 Oxaliplatin

Definition: A radioconjugate composed of the platinum agent oxaliplatin labeled with the isotope carbon C 14, that can be used to predict the response to oxaliplatin therapy using accelerator mass spectrometry (AMS). Upon intravenous administration of a microdose of carbon C 14 oxaliplatin, the oxaliplatin moiety covalently links to DNA and forms mono- and di-DNA adducts. The platinum-DNA adduct formation can be measured through quantification of C14-labeled drug-DNA adducts by using AMS. By measuring the microdose-induced DNA damage, the response to oxaliplatin-based chemotherapy can be assessed and predicted. Measurements that indicate either low drug-DNA adduct formation or increased DNA repair (C14 removal from DNA) are correlated with increased resistance to platinum-based chemotherapeutics.

Display Name: Carbon C 14 Oxaliplatin

Label: Carbon C 14 Oxaliplatin

NCI Thesaurus Code: C111572 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL453980  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[14C] Oxaliplatin
Carbon C 14 Oxaliplatin

External Source Codes: 
PDQ Closed Trial Search ID 752239
PDQ Open Trial Search ID 752239 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C111572
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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