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Version: 17.06d (Release date: 2017-06-26)
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MELK Inhibitor OTS167 (Code C111569)

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Terms & Properties

Preferred Name: MELK Inhibitor OTS167

Definition: An orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells.

Display Name: MELK Inhibitor OTS167

Label: MELK Inhibitor OTS167

NCI Thesaurus Code: C111569 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL453977  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MELK Inhibitor OTS167

External Source Codes: 
PDQ Closed Trial Search ID 751983
PDQ Open Trial Search ID 751983 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C111569
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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