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Version: 17.06d (Release date: 2017-06-26)
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Genistein (Code C1113)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Genistein

Definition: A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)

CRCH Definition: An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring.

NCI-GLOSS Definition: An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.

Display Name: Genistein

Label: Genistein

NCI Thesaurus Code: C1113 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0061202  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4',5,7-Trihydroxyisoflavone
4',5, 7-Trihydroxyisoflavone
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Genestein
Genistein
genistein
GENISTEIN
Genisteol
Prunetol

External Source Codes: 
CAS Registry Number 446-72-0 (see NLM ChemIDplus info)
FDA UNII Code DH2M523P0H
ChEBI ID CHEBI:28088 (see ChEBI info)
NSC Code 36586 (see NCI DTP info)
PDQ Closed Trial Search ID 43214
PDQ Open Trial Search ID 43214 (check for NCI PDQ open clinical trial info)
UMLS CUI C0061202

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H10O5
code C1113
Contributing_Source CRCH
Contributing_Source CTRP
Contributing_Source FDA
INFOODS GNSTEIN
Legacy_Concept_Name Genistein
Semantic_Type Organic Chemical
Unit mcg

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1113

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