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Version: 17.06d (Release date: 2017-06-26)
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Zirconium Zr 89 Df-IAB2M (Code C111040)

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Terms & Properties

Preferred Name: Zirconium Zr 89 Df-IAB2M

Definition: A radioimmunoconjugate comprised of an antibody fragment (IAB2M) against prostate-specific membrane antigen (PSMA), conjugated to the chelator desferrioxamine (Df) and labeled with the radioisotope zirconium Zr 89, with potential positron emission tomography (PET) imaging activity. Upon administration of zirconium Zr 89 Df-IAB2M, the antibody moiety binds to the extracellular domain of PSMA expressed on cancer cells. This may enable PET detection of the radioisotope moiety, and allows the imaging and quantification of PSMA-expressing tumor cells. PSMA is a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells in various solid tumor malignancies.

Display Name: Zirconium Zr 89 Df-IAB2M

Label: Zirconium Zr 89 Df-IAB2M

NCI Thesaurus Code: C111040 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL453547  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[89Zr]Df-IAB2M
Zirconium Zr 89 Df-IAB2M

External Source Codes: 
PDQ Closed Trial Search ID 751849
PDQ Open Trial Search ID 751849 (check for NCI PDQ open clinical trial info)
NCI META CUI CL453547

Other Properties:
     Name Value (qualifiers indented underneath)
code C111040
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111040

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