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Version: 17.06d (Release date: 2017-06-26)
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Fotemustine (Code C1106)

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Terms & Properties

Preferred Name: Fotemustine

Definition: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

NCI-GLOSS Definition: A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.

Label: Fotemustine

NCI Thesaurus Code: C1106 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060696  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester
[1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester
S 10036

External Source Codes: 
CAS Registry Number 92118-27-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 38865
PDQ Open Trial Search ID 38865 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060696

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H19ClN3O5P
code C1106
Contributing_Source FDA
Legacy_Concept_Name Fotemustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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