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Version: 17.06d (Release date: 2017-06-26)
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Fotemustine (Code C1106)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fotemustine

Definition: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

NCI-GLOSS Definition: A substance being studied in the treatment of brain tumors and metastatic melanoma of the eye. It is a type of nitrosourea.

Label: Fotemustine

NCI Thesaurus Code: C1106 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060696  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester
[1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester
diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate
Fotemustine
fotemustine
FOTEMUSTINE
Muphoran
S 10036

External Source Codes: 
CAS Registry Number 92118-27-9 (see NLM ChemIDplus info)
FDA UNII Code GQ7JL9P5I2
PDQ Closed Trial Search ID 38865
PDQ Open Trial Search ID 38865 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060696

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H19ClN3O5P
code C1106
Contributing_Source FDA
Legacy_Concept_Name Fotemustine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1106

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