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Version: 16.11d (Release date: 2016-11-28)
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Fludrocortisone Acetate (Code C1103)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fludrocortisone Acetate

Definition: The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

Label: Fludrocortisone Acetate

NCI Thesaurus Code: C1103 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0616274  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Florinef
Florinef Acetate
Florinef acetate
FLUDROCORTISONE ACETATE
Fludrocortisone Acetate
Fludrocortisone acetate

External Source Codes: 
CAS Registry Number 514-36-3 (see NLM ChemIDplus info)
FDA UNII Code V47IF0PVH4
NSC Code 15186 (see NCI DTP info)
PDQ Closed Trial Search ID 39243
PDQ Open Trial Search ID 39243 (check for NCI PDQ open clinical trial info)
UMLS CUI C0616274

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C23H31FO6
code C1103
Contributing_Source FDA
Legacy_Concept_Name Fludrocortisone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1103

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