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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Mitoflaxone (Code C1101)

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Terms & Properties

Preferred Name: Mitoflaxone

Definition: A synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation. (NCI04)

Label: Mitoflaxone

NCI Thesaurus Code: C1101 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060441  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4H-1-benzopyran-8-acetic Acid, 4-Oxo-2-phenyl
4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-
Flavone-8-Acetic Acid
Flavone acetic acid
Flavone Acetic Acid
LM 975

External Source Codes: 
CAS Registry Number 87626-55-9 (see NLM ChemIDplus info)
FDA UNII Code X230G6E63B
NSC Code 347512 (see NCI DTP info)
PDQ Closed Trial Search ID 40152
PDQ Open Trial Search ID 40152 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060441

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C17H12O4
code C1101
Contributing_Source FDA
Legacy_Concept_Name Flavone_Acetic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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