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Version: 16.10e (Release date: 2016-10-31)
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Finasteride (Code C1099)

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Terms & Properties

Preferred Name: Finasteride

Definition: A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation.

NCI-GLOSS Definition: A drug used to reduce the amount of male hormone (testosterone) produced by the body.

Display Name: Finasteride

Label: Finasteride

NCI Thesaurus Code: C1099 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060389  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Chibro-Proscar
Finasteride
FINASTERIDE
finasteride
Finastid
MK 906
Pro-Cure
Propecia
Propeshia
Proscar
Prostide
Urprosan

External Source Codes: 
CAS Registry Number 98319-26-7 (see NLM ChemIDplus info)
FDA UNII Code 57GNO57U7G
ChEBI ID CHEBI:5062 (see ChEBI info)
PDQ Closed Trial Search ID 41096
PDQ Open Trial Search ID 41096 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060389

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C23H36N2O2
code C1099
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Finasteride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1099

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