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Version: 16.11d (Release date: 2016-11-28)
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Fenretinide (Code C1098)

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Terms & Properties

Preferred Name: Fenretinide

Definition: An orally-active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis-associated growth factors and their receptors and exhibits retinoid receptor-independent apoptotic properties. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment and prevention of some types of cancer. Fenretinide may cause ceramide (a wax-like substance) to build up in tumor cells and kill them. It is a type of retinoid, which are substances related to vitamin A.

Display Name: Fenretinide

Label: Fenretinide

NCI Thesaurus Code: C1098 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060197  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-(all-trans-retino-yl)aminophenol
4-HPR
4-Hydroxyphenylretinamide
All-trans-4'-Hydroxyretinanilide
all-trans-4'-hydroxyretinanilide
all-trans-N-(4-Hydroxyphenyl)retinamide
all-trans-N-4'-hydroxyretinanilide
Fenretinide
FENRETINIDE
fenretinide
Fenretinimide
HPR-4
McN-R-1967
N-(4-hydroxyphenyl)retinamide

External Source Codes: 
CAS Registry Number 65646-68-6 (see NLM ChemIDplus info)
FDA UNII Code 187EJ7QEXL
ChEBI ID CHEBI:42588 (see ChEBI info)
NSC Code 374551 (see NCI DTP info)
PDQ Closed Trial Search ID 39582
PDQ Open Trial Search ID 39582 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060197

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C26H33NO2
code C1098
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Fenretinide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1098

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