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Version: 17.08d (Release date: 2017-08-28)
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Exemestane (Code C1097)

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Terms & Properties

Preferred Name: Exemestane

Definition: A synthetic androgen analogue. Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)

NCI-GLOSS Definition: A drug used to treat advanced breast cancer and to prevent recurrent breast cancer in postmenopausal women who have already been treated with tamoxifen. It is also being studied in the treatment of other types of cancer. Aromasin causes a decrease in the amount of estrogen made by the body. It is a type of aromatase inhibitor.

Display Name: Exemestane

Label: Exemestane

NCI Thesaurus Code: C1097 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0851344  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
6-Methyleneandrosta-1,4-diene-3,17-dione
Aromasin
Exemestane
EXEMESTANE
exemestane
FCE-24304

External Source Codes: 
CAS Registry Number 107868-30-4 (see NLM ChemIDplus info)
FDA UNII Code NY22HMQ4BX
ChEBI ID CHEBI:4953 (see ChEBI info)
NSC Code 713563 (see NCI DTP info)
PDQ Closed Trial Search ID 42297
PDQ Open Trial Search ID 42297 (check for NCI PDQ open clinical trial info)
UMLS CUI C0851344

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Estrogen Receptor-Positive Early Breast Cancer; early and advanced-stage breast cancer
Chemical_Formula C20H24O2
code C1097
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Exemestane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1097

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