skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Fazarabine (Code C1096)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fazarabine

Definition: An orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. (NCI04)

NCI-GLOSS Definition: An anticancer drug that is a type of antimetabolite.

Label: Fazarabine

NCI Thesaurus Code: C1096 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0060103  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI)
1,3, 5-Triazin-2(1H)-one, 4-Amino-1-beta-D- arabinofuranosyl- (9CI)
1-.beta.-D-Arabinofuranosyl-5-azacytosine
1-Beta-D-arabinofuranosyl-5-azacytosine
ara-AC
Ara AC
fazarabine
FAZARABINE
Fazarabine
Kymarabine

External Source Codes: 
CAS Registry Number 65886-71-7 (see NLM ChemIDplus info)
FDA UNII Code 5V71D8JOKK
NSC Code 281272 (see NCI DTP info)
PDQ Closed Trial Search ID 40564
PDQ Open Trial Search ID 40564 (check for NCI PDQ open clinical trial info)
UMLS CUI C0060103

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C8H12N4O5
code C1096
Contributing_Source FDA
Legacy_Concept_Name Fazarabine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1096

Mainbox Bottom