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Version: 17.06d (Release date: 2017-06-26)
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Etoposide Phosphate (Code C1093)

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Terms & Properties

Preferred Name: Etoposide Phosphate

Definition: A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)

NCI-GLOSS Definition: A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Etopophos blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.

Display Name: Etoposide Phosphate

Label: Etoposide Phosphate

NCI Thesaurus Code: C1093 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0059874  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Etoposide Phosphate
etoposide phosphate

External Source Codes: 
CAS Registry Number 117091-64-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42801
PDQ Open Trial Search ID 42801 (check for NCI PDQ open clinical trial info)
UMLS CUI C0059874

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute leukemia; Adrenal cortical cancer; Brain cancer; Chronic lymphocytic leukemia; Choriocarcinoma; Esophageal cancer; Ewings sarcoma; Gastric cancer; Germ cell cancer; Gestational trophoblastic neoplasms
Accepted_Therapeutic_Use_For Hepatocellular cancer; Hodgkins disease; Hypereosinophilic syndrome; Kaposis sarcoma; Testicular cancer; Thymoma; Thyroid cancer; Uterine cancer; Wilms tumor
Accepted_Therapeutic_Use_For Langerhans cell histiocytosis; Mobilization of peripheral-blood progenitor cells; Multiple myeloma; Neuroblastoma; Non-small lung cancer; Osteogenic sarcoma; Ovarian cancer; Retinoblastoma; Small cell lung cancer; Soft tissue sarcomas
Chemical_Formula C29H33O16P
code C1093
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Etoposide_Phosphate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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