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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Etanidazole (Code C1092)

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Terms & Properties

Preferred Name: Etanidazole

Definition: A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. (NCI04)

NCI-GLOSS Definition: A drug that increases the effectiveness of radiation therapy.

Display Name: Etanidazole

Label: Etanidazole

NCI Thesaurus Code: C1092 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0059682  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-
2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-

External Source Codes: 
CAS Registry Number 22668-01-5 (see NLM ChemIDplus info)
NSC Code 301467 (see NCI DTP info)
PDQ Closed Trial Search ID 39446
PDQ Open Trial Search ID 39446 (check for NCI PDQ open clinical trial info)
UMLS CUI C0059682

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C7H10N4O4
code C1092
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Etanidazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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