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Version: 17.06d (Release date: 2017-06-26)
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Elsamitrucin (Code C1080)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Elsamitrucin

Definition: An heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. (NCI04)

Label: Elsamitrucin

NCI Thesaurus Code: C1080 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0059041  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
10-O-Elsaminosylelsarosylchartarin
BBM 2478A
Benzo(h)(1)benzopyrano(5,4,3-cde)(1)ebnzopyran-5,12-dione,10((2-O-(2-amino-2,6-dideoxy-3-O-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl
BMY-28090
BRN 5214813
Elsamicin A
Elsamitrucin
ELSAMITRUCIN
Elsamitrucina
Elsamitrucine
Elsamitrucinum

External Source Codes: 
CAS Registry Number 97068-30-9 (see NLM ChemIDplus info)
FDA UNII Code ZTV0FOB6NU
PDQ Closed Trial Search ID 41409
PDQ Open Trial Search ID 41409 (check for NCI PDQ open clinical trial info)
UMLS CUI C0059041

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C33H35NO13
code C1080
Contributing_Source FDA
Legacy_Concept_Name Elsamitrucin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1080

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