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Version: 17.06d (Release date: 2017-06-26)
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BC-819 Plasmid/Polyethylenimine Complex (Code C107685)

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Terms & Properties

Preferred Name: BC-819 Plasmid/Polyethylenimine Complex

Definition: A plasmid DNA encoding for the A fragment of Diphtheria Toxin (DTA) under the control of the H19 gene promoter (BC-819 or DTA-H19) and mixed with the transfectant polyethylenimine (PEI), with potential antineoplastic activity. Upon administration, the PEI moiety enhances the entry of the agent into rapidly dividing cells. Upon cell entry, activation of the H19 gene promoter-containing plasmids and DTA expression are limited to tumor cells, as high levels of H19 expression are only found in tumor cells. DTA disrupts protein synthesis. Tumor-cell selective expression of this toxin leads to the selective destruction of the tumor while sparing healthy, normal cells. H19, an oncofetal, regulatory RNA, is overexpressed in certain cancer cells while its expression in normal cells is minimal or absent; it plays a key role in cancer progression, angiogenesis and metastasis.

Label: BC-819 Plasmid/Polyethylenimine Complex

NCI Thesaurus Code: C107685 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL451873  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BC-819/PEI
BC-819 Plasmid/Polyethylenimine Complex
DTA-H19/PEI

External Source Codes: 
PDQ Closed Trial Search ID 751613
PDQ Open Trial Search ID 751613 (check for NCI PDQ open clinical trial info)
NCI META CUI CL451873

Other Properties:
     Name Value (qualifiers indented underneath)
code C107685
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107685

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