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Version: 17.06d (Release date: 2017-06-26)
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Melphalan-Flufenamide Prodrug (Code C107680)

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Terms & Properties

Preferred Name: Melphalan-Flufenamide Prodrug

Definition: A melphalan prodrug in which the alkylating agent melphalan is bound to flufenamide, with potential antineoplastic and anti-angiogenic activities. Upon administration, the dipeptide bond in the melphalan-flufenamide compound is hydrolyzed by peptidases, which are overexpressed by certain cancer cells. This results in the specific release and accumulation of the active metabolite melphalan in cancer cells. Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages. This results in the inhibition of DNA and RNA synthesis and the induction of apoptosis, thereby inhibiting tumor cell proliferation. The administration of the melphalan-flufenamide prodrug allows for enhanced efficacy and reduced toxicity compared to melphalan alone.

Display Name: Melphalan-Flufenamide Prodrug

Label: Melphalan-Flufenamide Prodrug

NCI Thesaurus Code: C107680 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1435750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
J1
L-melphalanyl-p-L-fluorophenylalanine Ethyl Ester
Melphalan-Flufenamide Prodrug

External Source Codes: 
PDQ Closed Trial Search ID 751473
PDQ Open Trial Search ID 751473 (check for NCI PDQ open clinical trial info)
UMLS CUI C1435750

Other Properties:
     Name Value (qualifiers indented underneath)
code C107680
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107680

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