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Version: 17.06d (Release date: 2017-06-26)
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CD138CAR-CD137/TCRzeta-expressing T Lymphocytes (Code C107505)

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Terms & Properties

Preferred Name: CD138CAR-CD137/TCRzeta-expressing T Lymphocytes

Definition: T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR- CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of syndecan-1. Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed in a variety of cancer cells. It plays a key role in the regulation of cell growth, differentiation, and adhesion, and its expression is correlated with poor prognosis.

Display Name: CD138CAR-CD137/TCRzeta-expressing T Lymphocytes

Label: CD138CAR-CD137/TCRzeta-expressing T Lymphocytes

NCI Thesaurus Code: C107505 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL451751  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CART-138 TCR zeta:CD137
CD138CAR-CD137/TCRzeta-expressing T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 751382
PDQ Open Trial Search ID 751382 (check for NCI PDQ open clinical trial info)
NCI META CUI CL451751

Other Properties:
     Name Value (qualifiers indented underneath)
code C107505
Contributing_Source CTRP
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107505

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