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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Adenovirus Type 5 H101 (Code C107504)

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Terms & Properties

Preferred Name: Recombinant Human Adenovirus Type 5 H101

Definition: A replication selective, recombinant, E1B and partial E3 gene deleted form of human adenovirus type 5, with potential antineoplastic activity. Upon intratumoral injection of recombinant human adenovirus type 5, the adenovirus selectively replicates in cancer cells while preventing viral replication in normal, healthy cells. This induces a selective adenovirus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. In addition, viral spread to adjacent cells, following lysis of infected cells, may activate the immune system to kill the infected tumor cells. The E1B protein causes p53 inactivation, which promotes viral replication; deletion of E1B allows for p53 activation in normal cells, which prevents viral replication in normal, healthy cells. The mutation and subsequent inactivation of p53 in cancer cells enables the E1B-deleted adenovirus to selectively replicate in cancer cells. Partial deletion of E3, encoding the adenovirus death protein, enhances the safety profile of the administered adenovirus.

Label: Recombinant Human Adenovirus Type 5 H101

NCI Thesaurus Code: C107504 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL451750  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
H101
Oncorine
rAd5 H101
Recombinant Human Adenovirus Type 5 H101

External Source Codes: 
PDQ Closed Trial Search ID 751381
PDQ Open Trial Search ID 751381 (check for NCI PDQ open clinical trial info)
NCI META CUI CL451750

Other Properties:
     Name Value (qualifiers indented underneath)
code C107504
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107504

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