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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 124 Phospholipid Ether Analogue CLR1404 (Code C107500)

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Terms & Properties

Preferred Name: Iodine I 124 Phospholipid Ether Analogue CLR1404

Definition: A small molecule radiopharmaceutical composed of the radioisotope iodine I 124 covalently attached to a proprietary alkylphospholipid ether (PLE) analogue, with potential imaging activity upon positron emission tomography (PET). Iodine I 124 phospholipid ether analogue CLR1404 is selectively taken up by tumor cells via membrane lipid rafts and accumulates in tumor cells. The accummulation of this agent is due to a decreased ability of tumor cells to metabolize PLEs because certain tumor cells have lower levels of the enzyme phospholipase-D, in comparison to normal cells. This facilitates imaging of cancer cells by PET. Lipid rafts, specialized microdomains of plasma membrane, are overexpressed in cancer cells compared to normal cells. In addition, the radioiodine moiety of this agent is resistant to de-iodination.

Display Name: Iodine I 124 Phospholipid Ether Analogue CLR1404

Label: Iodine I 124 Phospholipid Ether Analogue CLR1404

NCI Thesaurus Code: C107500 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL451746  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18-(p-[I-124]iodophenyl) Octadecyl Phosphocholine
I-124-CLR1404
I-124-NM404
Iodine I 124 Phospholipid Ether Analogue CLR1404

External Source Codes: 
PDQ Closed Trial Search ID 751301
PDQ Open Trial Search ID 751301 (check for NCI PDQ open clinical trial info)
NCI META CUI CL451746

Other Properties:
     Name Value (qualifiers indented underneath)
code C107500
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107500

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