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Version: 17.06d (Release date: 2017-06-26)
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BP-Cx1-Platinum Complex BP-C1 (Code C107387)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BP-Cx1-Platinum Complex BP-C1

Definition: A combination agent composed of the benzo-poly-carbonic-acid polymer BP-Cx1 chelated to platinum with potential antineoplastic activity. Upon intramuscular injection, the polymer moiety of BP-Cx1-Platinum Complex BP-C1 (BP-C1) alters the permeability of the cell membranes, which allows for increased penetration of platinum into tumor cells. In turn, platinum binds to nucleophilic groups such as GC-rich sites in DNA and induces intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. In addition, the BP-Cx1 ligand is able to stimulate the innate immune system and upregulates a variety of cytokines including interferon, tumor necrosis factor-alpha (TNF-alpha), granulocyte macrophage-colony stimulating factor (GM-CSF), and various interleukins (ILs) such as IL-6 and IL-25. In comparison to cisplatin and other platinum-based compounds, treatment with BP-C1 allows for less platinum administration, which reduces platinum-associated systemic toxicity and side effects, and enhances the safety profile while maintaining or improving its efficacy.

Label: BP-Cx1-Platinum Complex BP-C1

NCI Thesaurus Code: C107387 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449598  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BP-C1
BP-Cx1-Platinum Complex BP-C1

External Source Codes: 
PDQ Closed Trial Search ID 751002
PDQ Open Trial Search ID 751002 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449598

Other Properties:
     Name Value (qualifiers indented underneath)
code C107387
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107387

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