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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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PI3K Inhibitor WX-037 (Code C107386)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PI3K Inhibitor WX-037

Definition: A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor WX-037 specifically inhibits PI3K, which prevents the activation of the PI3K/protein kinase B-mediated signaling pathway. This may result in the inhibition of both tumor cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Label: PI3K Inhibitor WX-037

NCI Thesaurus Code: C107386 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449597  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PI3K Inhibitor WX-037
WX-037

External Source Codes: 
PDQ Closed Trial Search ID 750893
PDQ Open Trial Search ID 750893 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449597

Other Properties:
     Name Value (qualifiers indented underneath)
code C107386
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107386

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