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Version: 17.06d (Release date: 2017-06-26)
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MDM2 Inhibitor DS-3032b (Code C107384)

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Terms & Properties

Preferred Name: MDM2 Inhibitor DS-3032b

Definition: An orally available MDM2 (murine double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it has been implicated in cancer cell proliferation and survival.

Display Name: MDM2 Inhibitor DS-3032b

Label: MDM2 Inhibitor DS-3032b

NCI Thesaurus Code: C107384 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449595  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DS-3032b
HDM2 Inhibitor DS-3032b
MDM2 Inhibitor DS-3032b

External Source Codes: 
PDQ Closed Trial Search ID 750863
PDQ Open Trial Search ID 750863 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449595

Other Properties:
     Name Value (qualifiers indented underneath)
code C107384
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107384

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