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Version: 17.06d (Release date: 2017-06-26)
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CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes (Code C107242)

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Terms & Properties

Preferred Name: CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes

Definition: Allogeneic T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD19CAR-CD28 zeta-4-1BB-expressing allogeneic T lymphocytes directs the T-lymphocytes to and induces selective toxicity in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies.

Label: CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes

NCI Thesaurus Code: C107242 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449496  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic CD19.CAR/28137zeta T-lymphocytes
CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 750848
PDQ Open Trial Search ID 750848 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449496

Other Properties:
     Name Value (qualifiers indented underneath)
code C107242
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107242

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