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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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ERK Inhibitor GDC-0994 (Code C107241)

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Terms & Properties

Preferred Name: ERK Inhibitor GDC-0994

Definition: An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.

Display Name: ERK Inhibitor GDC-0994

Label: ERK Inhibitor GDC-0994

NCI Thesaurus Code: C107241 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449495  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ERK Inhibitor GDC-0994

External Source Codes: 
PDQ Closed Trial Search ID 750790
PDQ Open Trial Search ID 750790 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C107241
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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