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Version: 17.06d (Release date: 2017-06-26)
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FACT Complex-targeting Curaxin CBL0137 (Code C107239)

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Terms & Properties

Preferred Name: FACT Complex-targeting Curaxin CBL0137

Definition: An orally available curaxin-based agent targeting the Facilitates Chromatin Transcription (FACT) complex, with potential antineoplastic activity. Upon administration, CBL0137 binds to FACT and sequesters the FACT complex on chromatin, which inhibits its activity. This prevents transcription of certain genes involved in cancer-associated signaling pathways; it specifically inhibits the transcription of both NF-kappa B and heat shock transcription factor 1 (HSF1) and simultaneously activates p53. This causes an increase in tumor cell apoptosis and a decrease in tumor cell proliferation, in FACT-positive cancers. In addition, this agent is able to sensitize FACT-positive tumor cells to the cytotoxic effects of other chemotherapeutic agents. FACT, a transcription and replication factor composed of the Structure Specific Recognition Protein (SSRP1) and suppressor of Ty 16 (Spt16) proteins, is expressed in a variety of tumor cells while almost absent in normal cells; its expression is associated with increased tumor aggressiveness and poor prognosis.

Display Name: FACT Complex-targeting Curaxin CBL0137

Label: FACT Complex-targeting Curaxin CBL0137

NCI Thesaurus Code: C107239 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827145  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FACT Complex-targeting Curaxin CBL0137

External Source Codes: 
PDQ Closed Trial Search ID 750614
PDQ Open Trial Search ID 750614 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827145

Other Properties:
     Name Value (qualifiers indented underneath)
code C107239
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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