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Version: 17.06d (Release date: 2017-06-26)
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FAK Inhibitor VS-4718 (Code C107238)

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Terms & Properties

Preferred Name: FAK Inhibitor VS-4718

Definition: An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic activity. Upon administration, VS-4718 inhibits FAK, blocks fibronectin-stimulated FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt. This results in the reduction of the number of cancer stem cells (CSCs) and inhibits tumor cell migration, proliferation and survival. The cytoplasmic tyrosine kinase FAK is a signal transducer for integrins and is constitutively activated in various tumor cell types; it is involved in tumor cell invasion, migration and proliferation and plays a key role in the development, function and survival of CSCs.

Display Name: FAK Inhibitor VS-4718

Label: FAK Inhibitor VS-4718

NCI Thesaurus Code: C107238 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3177516  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FAK Inhibitor VS-4718

External Source Codes: 
PDQ Closed Trial Search ID 750562
PDQ Open Trial Search ID 750562 (check for NCI PDQ open clinical trial info)
UMLS CUI C3177516

Other Properties:
     Name Value (qualifiers indented underneath)
code C107238
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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