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Version: 17.06d (Release date: 2017-06-26)
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EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes (Code C107191)

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Terms & Properties

Preferred Name: EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

Definition: Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis.

Label: EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

NCI Thesaurus Code: C107191 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449451  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CART-EGFR TCR zeta:CD137 Cells
EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 750510
PDQ Open Trial Search ID 750510 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449451

Other Properties:
     Name Value (qualifiers indented underneath)
code C107191
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107191

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