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Version: 17.06d (Release date: 2017-06-26)
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CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes (Code C107190)

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Terms & Properties

Preferred Name: CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

Definition: Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD33 scFv (single chain variable fragment) coupled to the signaling domain of 4-1BB (CD137) and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD33-specific CAR retroviral vector-transduced autologous T lymphocytes target CD33-expressing tumor cells and induce selective toxicity in CD33-expressing tumor cells. Following binding to CD33, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. CD33 is expressed on normal non-pluripotent hematopoietic stem cells as well as on myeloid leukemia cells.

Label: CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

NCI Thesaurus Code: C107190 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449450  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-CD33 TCR zeta:CD137 CAR T Cells
CART-33 TCR zeta:CD137 Cells
CART33 TCR zeta:CD137 Cells
CD33CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 750489
PDQ Open Trial Search ID 750489 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449450

Other Properties:
     Name Value (qualifiers indented underneath)
code C107190
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107190

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