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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine (Code C107169)

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Terms & Properties

Preferred Name: Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine

Definition: An allogeneic melanoma cell vaccine derived from a cell line with high expression of melanoma associated antigens and genetically modified to express both HLA-A2 and 4-1BB ligand, with potential immunostimulating and antineoplastic activities. Upon administration, the 4-1BB ligand of the allogeneic HLA-A2/4-1BB ligand-expressing melanoma vaccine binds to 4-1BB on activated T-lymphocytes, which induces a strong immune response against HLA-A2 positive melanoma cells.

Label: Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine

NCI Thesaurus Code: C107169 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449429  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic HLA-A2/4-1BB ligand-expressing Melanoma Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 750454
PDQ Open Trial Search ID 750454 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449429

Other Properties:
     Name Value (qualifiers indented underneath)
code C107169
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107169

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