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Version: 17.06d (Release date: 2017-06-26)
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pBCAR3/pIRS2-Phosphopeptide-tetanus Peptide Vaccine (Code C107168)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: pBCAR3/pIRS2-Phosphopeptide-tetanus Peptide Vaccine

Definition: A vaccine composed of phosphorylated peptides from the tumor associated antigens breast cancer anti-estrogen resistance-3 (BCAR3) and insulin receptor substrate-2 (IRS2) and a tetanus-derived peptide, with potential immunomodulating and antineoplastic activities. Upon administration of pBCAR3/pIRS2 phosphopeptide-tetanus peptide vaccine, the pBCAR3/pIRS2 phosphopeptide may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing either phosphopeptide. The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response which may help stimulate an immune response against pBCAR3 and pIRS2-expressing melanoma tumor cells. BCAR3 and IRS2 are upregulated in a variety of cancer cells.

Label: pBCAR3/pIRS2-Phosphopeptide-tetanus Peptide Vaccine

NCI Thesaurus Code: C107168 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449428  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-MpP Phosphopeptide-tetanus Peptide Vaccine
pBCAR3/pIRS2-Phosphopeptide-tetanus Peptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 750410
PDQ Open Trial Search ID 750410 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449428

Other Properties:
     Name Value (qualifiers indented underneath)
code C107168
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107168

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