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Version: 17.06d (Release date: 2017-06-26)
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Benzaldehyde Dimethane Sulfonate (Code C107164)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Benzaldehyde Dimethane Sulfonate

Definition: A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, benzaldehyde dimethane sulfonate alkylates DNA, which results in DNA double strand breaks, inhibition of DNA replication, cell cycle arrest and cell death. In addition, this agent is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the active carboxylic acid metabolite benzoic acid dimethane sulfonate (BA), which further contributes to its alkylating activity. Unlike other alkylating agents, benzaldehyde dimethane sulfonate has demonstrated antitumor activity in renal cell carcinoma.

Display Name: Benzaldehyde Dimethane Sulfonate

Label: Benzaldehyde Dimethane Sulfonate

NCI Thesaurus Code: C107164 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3661349  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BEN
Benzaldehyde Dimethane Sulfonate
DMS-612
DMS612
NSC 281612

External Source Codes: 
FDA UNII Code 96B0BRI1JU
PDQ Closed Trial Search ID 750365
PDQ Open Trial Search ID 750365 (check for NCI PDQ open clinical trial info)
UMLS CUI C3661349

Other Properties:
     Name Value (qualifiers indented underneath)
code C107164
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107164

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