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Version: 17.06d (Release date: 2017-06-26)
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Gallium Ga 68-labeled Affibody ABY-025 (Code C107163)

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Terms & Properties

Preferred Name: Gallium Ga 68-labeled Affibody ABY-025

Definition: A radioconjugate composed of an optimized affibody conjugated, via its C-terminal cysteine, to maleimide-DOTA, and linked to the radioisotope gallium Ga 68, with potential use as a tracer for human epidermal growth factor receptor type 2 (HER2; ErbB2)-expressing tumors using positron emission tomography (PET). Upon intravenous administration of the gallium Ga 68-labeled affibody ABY-025, the affibody targets HER2-expressing tumor cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeting chemotherapeutic agents during PET imaging. The affibody is an optimized antibody mimetic based on a 6.5-kDa 3-helical bundle Z domain derived from the staphylococcal protein A (Z her2:342); the nonbinding surface of the Z domain is reengineered (Z her2:2891) to increase binding affinity for HER2 and to improve tumor imaging. HER2 is overexpressed in many cancer cell types.

Label: Gallium Ga 68-labeled Affibody ABY-025

NCI Thesaurus Code: C107163 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449424  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[68Ga]ABY-025
Gallium Ga 68-[maleimide-DOTA-Cys61]-ZHER2:2891-Cys
Gallium Ga 68-labeled Affibody ABY-025

External Source Codes: 
PDQ Closed Trial Search ID 750369
PDQ Open Trial Search ID 750369 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449424

Other Properties:
     Name Value (qualifiers indented underneath)
code C107163
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107163

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