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Version: 17.06d (Release date: 2017-06-26)
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Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells (Code C107160)

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Terms & Properties

Preferred Name: Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells

Definition: Bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway.

Label: Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells

NCI Thesaurus Code: C107160 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL449421  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Celyvir
Oncolytic Adenovirus ICOVIR5-infected Autologous Mesenchymal Stem Cells

External Source Codes: 
PDQ Closed Trial Search ID 750329
PDQ Open Trial Search ID 750329 (check for NCI PDQ open clinical trial info)
NCI META CUI CL449421

Other Properties:
     Name Value (qualifiers indented underneath)
code C107160
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C107160

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