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Version: 17.06d (Release date: 2017-06-26)
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Porfimer Sodium (Code C1071)

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Terms & Properties

Preferred Name: Porfimer Sodium

Definition: The sodium salt of a mixture of oligomers formed by ether and ester linkages of up to eight porphyrin units with photodynamic activity. Absorbed selectively by tumor cells, porfimer produces oxygen radicals after activation by 630 nm wavelength laser light, resulting in tumor cell cytotoxicity. In addition, tumor cell death may occur due to ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by the release of thromboxane A2.

NCI-GLOSS Definition: A drug used to treat some types of cancer. When absorbed by cancer cells and exposed to light, porfimer sodium becomes active and kills the cancer cells. It is a type of photodynamic therapy agent.

Display Name: Porfimer Sodium

Label: Porfimer Sodium

NCI Thesaurus Code: C1071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1130428  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CL-184116
DHE
Dihematoporphyrin Ester
dihematoporphyrin ether
Dihematoporphyrin Ether
Photofrin II
Porfimer Sodium
PORFIMER SODIUM
porfimer sodium

External Source Codes: 
CAS Registry Number 87806-31-3 (see NLM ChemIDplus info)
FDA UNII Code Y3834SIK5F
ChEBI ID CHEBI:60773 (see ChEBI info)
NSC Code 265328 (see NCI DTP info)
NSC Code 603062 (see NCI DTP info)
PDQ Closed Trial Search ID 40294
PDQ Open Trial Search ID 40294 (check for NCI PDQ open clinical trial info)
UMLS CUI C1130428

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Photosensitizer, bladder, esophagel, gastric, lung and rectal cancer
Chemical_Formula (C34H35N4NaO5)n.(C34H33N4NaO4)n
code C1071
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Porfimer_Sodium
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1071

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